bcl-2 and bax expression in skin flaps treated with finasteride or azelaic acid

نویسندگان

seyyed abdulmajid ayatollahi department of pharmacognosy, school of pharmacy, shahid beheshti university, m.c., tehran, iran. school of pharmacy and phytochemistry research centre, shahid beheshti university of medical sciences, tehran, iran.

marjan ajami faculty of nutrition sciences and food technology, shahid beheshti university of medical sciences and health services.

hamed reyhanfard school of pharmacy and phytochemistry research centre, shahid beheshti university of medical sciences, tehran, iran.

yasin asadi physiology research center, tehran university of medical sciences, tehran, iran.

چکیده

despite all modern surgical techniques, skin flap that is considered as the main method in most reconstructive surgeries puts the skin tissue at danger of necrosis and apoptosis derived from ischemia. therefore, finding a treatment for decreasing the apoptosis derived from flap ischemia will be useful in clinic. in present study, we evaluated the effect of azelaic acid 20% and finasteride on expression of bcl-2 and bax proteins after the skin flap surgery. for this purpose, 21 rats were entered in three groups including control, azelaic acid 20% and finasteride, all experienced skin flap surgery and then flap tissue was assessed for determining the expression of proteins in 5 slices prepared from each rat that were graded between – to +++ scales. both azelaic acid and finasteride increased the expression of bcl-2 protein (p < 0.05) and decrease the expression of bax protein (p < 0.05). these results suggested an antiapoptotic role for finasteride and azelaic acid in preserving the flap after the ischemia reperfusion insult.

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BCL-2 and Bax Expression in Skin Flaps Treated with Finasteride or Azelaic Acid

Despite all modern surgical techniques, skin flap that is considered as the main method in most reconstructive surgeries puts the skin tissue at danger of necrosis and apoptosis derived from ischemia. Therefore, finding a treatment for decreasing the apoptosis derived from flap ischemia will be useful in clinic. In present study, we evaluated the effect of azelaic acid 20% and finasteride on ex...

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BCL-2 and Bax Expression in Skin Flaps Treated with Finasteride or Azelaic Acid

Despite all modern surgical techniques, skin flap that is considered as the main method in most reconstructive surgeries puts the skin tissue at danger of necrosis and apoptosis derived from ischemia. Therefore, finding a treatment for decreasing the apoptosis derived from flap ischemia will be useful in clinic. In present study, we evaluated the effect of azelaic acid 20% and finasteride on ex...

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BCL-2 and Bax Expression in Skin Flaps Treated with Finasteride or Azelaic Acid

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عنوان ژورنال:
the iranian journal of pharmaceutical research

جلد ۱۱، شماره ۴، صفحات ۱۲۸۵-۱۲۹۰

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